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Understanding diseases of aging: ageless woman

Recent and decisive scientific discoveries

1999-2000 (1)

The nerve cells in culture treated with testosterone secrete less amyloidogenic peptides.

Conclusion of this study: Androgens could be protection against the development of Alzheimer's disease (1).

2001 (2)

The first clinical description of the increase in the level of β-amyloid protein in the blood was published in 2001 by a team of researchers from the University of Western Australia in Perth (2). They demonstrated that:

Chemical castration causes the collapse of testosterone and plasma estradiol in humans in parallel with the elevation of amyloid beta protein

Chemical Andropause and Amyloid-beta Peptide
(JAMA. 2001;285:2195-2196)

Andropause, Alzheimer and peptide amyloïde B

Figure. Plasma Concentrations of Amyloid-beta Peptide (Abeta), Testosterone, and 17beta-Estradiol From 6 Men With Adenocarcinoma of the Prostate. Plasma concentrations were determined serially on samples drawn 1 week prior to initiating treatment with flutamide and leuprorelin acetate and on weeks 4, 12, and 24.

Conclusion de cette étude : le remplacement hormonal peut prévenir ou retarder la maladie d'Alzheimer chez l'homme andropausé

2004 (3)

In 2004 researchers at the University of Southern California "studied the testosterone content of the brain in deceased men. Two groups were studied:
The first group had no neuropathological abnormality (control group),
The second group had either Alzheimer's disease or moderate neuropathological disorders.

Conclusion of this study: the brain tissue of patients with Alzheimer's disease contains significantly less testosterone than the brain tissue of men with no neurophysiological abnormality (3)

2006 (4)

A clinical study was conducted for two years by researchers at the Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA., by a double-blind study of 16 men with Alzheimer's disease compared to 22 men without neurological problems, all treated with testosterone.

Conclusion of this study: the quality of life of men with Alzheimer's disease treated with testosterone was improved in general. Testosterone had a minimal effect on cognition (4).

2008 (5)

Emily R. Rosario and Christian J. Pike of the Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 USA publish a review of scientific publications devoted to Alzheimer's disease. Download pdf. (5)

Conclusion of this review:

  • Alzheimer's disease demonstrates an abnormal accumulation of amyloid β-protein in the brain.

  • Recent data suggest the regulatory action of androgens on amyloid β protein and on the development of Alzheimer's disease.

  • Androgen therapy can be considered to prevent and treat Alzheimer's disease

2011 (6)

An article in the American Academy of Family Physicians highlights the contradictions in the treatment of Alzheimer's disease with testosterone (6)


Hopes uncovered - news as of November 23, 2016

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Testosterone production decreases with age in men and women

The androgen production chain in women

Recent and decisive scientific discoveries

Hopes that will not be disappointed to prevent Alzheimer's disease

Understanding diseases of aging: ageless woman





A drug can only reach the diseased areas of the brain if the cerebral arteries are permeable.

Therefore, in order for natural molecules such as hormones or drug molecules to reach the brain cells, it is essential to first keep the cerebral arteries healthy.

Alzheimer in short